Hyperkalaemia and impaired renal function in patients taking spironolactone for congestive heart failure: retrospective study.

نویسندگان

  • Morten Svensson
  • Finn Gustafsson
  • Søren Galatius
  • Per R Hildebrandt
  • Dan Atar
چکیده

1 Lie RT, Rasmussen S, Brunborg H, Gjessing HK, Lie-Nielsen E, Irgens LM. Fetal and maternal contributions to risk of pre-eclampsia: population-based study. BMJ 1998;316:1343-7. 2 Basso O, Olsen J, Christensen K. Recurrence risk of congenital anomalies—the impact of paternal, social, and environmental factors: a population-based study in Denmark. Am J Epidemiol 1999;150:598-604. 3 Li DK. Changing paternity and the risk of preterm delivery in the subsequent pregnancy. Epidemiology 1999;10:148-52. 4 Dekker GA, Robillard PY, Hulsey TC. Immune maladaptation in the etiology of preeclampsia: a review of corroborative epidemiologic studies. Obstet Gynecol Surv 1998;53:377-82. 5 Skjærven R,Wilcox AJ, Lie RT. The interval between pregnancies and the risk of preeclampsia.N Engl J Med 2002;346:33-8. 6 Hoffman S, Hatch MC. Stress, social support and pregnancy outcome: a reassessment based on recent research. Paediatr Perinat Epidemiol 1996;10:380-405. 7 Jacobsen G, Schei B, Hoffman HJ. Psychosocial factor and small-forgestational-age infants among parous Scandinavian women. Acta Obstet Gynecol Scand Suppl 1997;165:14-8. 8 Parker JD, Schoendorf KC, Kiely JL. Associations between measures of socio-economic status and low birth weight, small for gestational age, and premature delivery in the United States. Ann Epidemiol 1994;4:271-8. 9 McMunn AM, Nazroo JY, Marmot MG, Boreham R, Goodman R. Children’s emotional and behavioural well-being and the family environment: findings from the Health Survey for England. Soc Sci Med 2001;53:423-40. 10 Heck KE, Schoendorf KC, Ventura SJ, Kiely JL. Delayed childbearing by education level in the United States, 1969-1994. Matern Child Health J 1997;1:81-8. 11 Statistics Norway.Norwegian standard for educational grouping. Oslo: Statistics Norway, 2000. (NOS C617.) 12 Shiono PH, Klebanoff MA, Rhoads GG. Smoking and drinking during pregnancy. Their effects on preterm birth. JAMA 1986;255:82-5. 13 Wilcox AJ. Birth weight and perinatal mortality. The effect of maternal smoking. Am J Epidemiol 1993;137:1098-104.

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Hyperkalaemia in congestive heart failure patients using ACE inhibitors and spironolactone.

BACKGROUND Recent studies have shown a fall in global mortality with minimal side effects in severe congestive heart failure (CHF) patients receiving angiotensin-converting enzyme inhibitors (ACEI) plus spironolactone (SLN). However, the risk of hyperkalaemia due to ACEI may be increased by the concomitant use of SLN. METHODS We conducted a retrospective cohort study by examining consecutive ...

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Spironolactone use and renal toxicity: population based longitudinal analysis.

OBJECTIVE To determine the safety of spironolactone prescribing in the setting of the UK National Health Service. DESIGN Population based longitudinal analysis using a record linkage database. SETTING Tayside, Scotland. Population All patients who received one or more dispensed prescriptions for spironolactone between 1994 and 2007. MAIN OUTCOME MEASURES Rates of prescribing for spironola...

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Increasing hospital admissions for systemic allergic disorders in England: analysis of national admissions data.

each 10% increase) were independent risk factors for azotaemia. For severe hyperkalaemia (serum potassium > 6.0 mmol/l) we added to the model baseline serum creati-nine concentration and whether the patient was taking potassium supplementation. In this analysis the NYHAFC (3.36 (1.17 to 9.69) for each class) and lower LVEF (0.37 (0.15 to 0.95) for each 10% increase) were predictive factors. Com...

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To bind or not to bind: potassium-lowering drugs in heart failure.

More than a decade ago the first large randomized controlled trial studying the effects of spironolactone in heart failure patients was published. The Randomized Aldactone Evaluation Study (RALES) trial showed for the first time the robust effects of aldosterone receptor blockers on reducing mortality. In this landmark trial patients with systolic heart failure in New York Heart Association (NY...

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Serious adverse events experienced by patients with chronic heart failure taking spironolactone.

In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia. In some cases this seems to happen because spironolactone causes diarrhoea. Four cases involving men with New York Heart Association functional class III heart failure are presented. As these cases revealed, close monitoring of blood chemistry is man...

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Precipitating factors of congestive heart failure in admitted patients of Fatemieh Hospital in Semnan, Iran

Introduction: Congestive Heart Failure (CHF) is a pathophysiologic state in which an abnormality of cardiac function is responsible for the failure of the heart to pump blood at a commensurate rate with the requirements of the metabolizing tissues and/or allows it to do so only from an abnormally elevated diastolic volume. In this study, the prevalence of precipitating factors of CHF in Semna...

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عنوان ژورنال:
  • BMJ

دوره 327 7424  شماره 

صفحات  -

تاریخ انتشار 2003